c-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas
نویسندگان
چکیده
منابع مشابه
MET expression and copy number heterogeneity in nonsquamous non-small cell lung cancer (nsNSCLC)
OBJECTIVE We aimed to assess MET intratumoral heterogeneity and its potential impact on biomarker-based patient selection as well as potential surrogate biomarkers of MET activation. METHODS Our study included 120 patients with non-squamous Non-small-cell Lung Cancer (nsNSCLC), of which 47 were incorporated in tissue microarrays (TMA). Four morphologically distinct tumor areas were selected t...
متن کاملPrognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer
The aim of this study was to analyze the correlation of the expression of MET and cyclin D1 and MET gene copy number in non-small cell lung cancer (NSCLC) tissues and patient clinicopathologic characteristics and survival. Sixty-one NSCLC tissue specimens were included in the study. The expression of MET and cyclin D1 was evaluated by immunohistochemistry and MET gene copy number was assessed b...
متن کاملEvaluation of HER2, MDM2, MYC, MET and TP53 gene copy number alterations in gastric cancer patients
Background: Gastric cancer (GC) is considered as one of the most common types of cancer worldwide with poor prognosis and generally limited treatment options. Recent studies have indicated that HER2, MDM2, MYC, MET, and TP53 play an important role in the development of gastric cancer. Therefore, the aim of this study was to evaluate the incidence of amplification/deletion of these genes in pati...
متن کاملStudy of MET protein levels and MET gene copy number in 72 sinonasal intestinal-type adenocarcinomas.
BACKGROUND Sinonasal intestinal-type adenocarcinomas (ITACs) have a poor prognosis, and are defined on the basis of their morphological similarities to colorectal adenocarcinomas. MET signaling pathway is involved in oncogenesis in various cancers. Nothing is currently known about the role of MET in ITACs. METHODS In a series of 72 ITACs, we investigated MET protein levels by immunohistochemi...
متن کاملIncreased MET Gene Copy Number but Not mRNA Level Predicts Postoperative Recurrence in Patients with Non–Small Cell Lung Cancer1
The aim of the present study was to investigate the relationship of MET copy number (CN) and MET mRNA expression to other molecular alterations, clinicopathologic characteristics, and survival of patients with resected non-small cell lung cancer. One hundred fifty-one paired surgical samples of tumor and tumor-distant normal lung tissues were analyzed by comparative quantitative polymerase chai...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2012
ISSN: 1556-0864
DOI: 10.1097/jto.0b013e318241655f